Ultimate TrumpRx Guide: Save 70% on GLP-1 Weight Loss Drugs (Wegovy, Mounjaro) in 2026
The landscape of American healthcare changed on February 5, 2026, with the official launch of TrumpRx.gov. Designed as a "Most-Favored-Nation" (MFN) portal, the site aims to ensure Americans pay the same low prices for medications as patients in Europe and other developed nations.
If you are currently paying $1,000+ per month for weight loss medications like Wegovy or Zepbound, this guide explains exactly how to use the new federal portal to slash those costs.
What is TrumpRx?
TrumpRx is a federal government-run clearinghouse that connects patients directly to pharmaceutical manufacturers. It is not a pharmacy itself; instead, it acts as a "front door" to bypass traditional middlemen (like PBMs) and insurance hurdles.
Through deals with giants like Eli Lilly, Novo Nordisk, and Pfizer, the platform offers "Gold-Embossed Coupons" and direct-to-consumer links that provide immediate price relief for cash-pay and Medicare patients.
2026 Weight Loss Drug Pricing (TrumpRx vs. Retail)
The most significant impact of TrumpRx is seen in the "GLP-1" category. Here is the official 2026 pricing for the most popular weight loss and diabetes medications available through the portal:
| Medication | Standard List Price | TrumpRX Cash Price | Medicare Copay |
| Wegovy (Injectable) | $1,349 | $350 (as low as $199*) | $50 |
| Zepbound | $1,088 | $346 (as low as $299*) | $50 |
| Ozempic | $1,028 | $350 | $50 |
| Mounjaro | $1,069 | $350 | $50 |
| Wegovy (Oral / Pill) | $1,349 | $150 (introductory) | $50 |
*Note: "As low as" pricing often applies to starter doses or the first 2 months of treatment.
How to Use TrumpRx: A Step-by-Step Guide
Accessing these prices requires a specific process. You cannot simply walk into a pharmacy and ask for the "Trump Price" without the proper documentation.
- Visit TrumpRx.gov: Ensure you are on the official
.govsite to avoid "clone" scams. - Generate Your Gold Coupon: Search for your medication (e.g., Zepbound). The site will generate a digital or printable "Gold-Embossed Coupon".
- Pharmacy vs. Direct-to-Consumer: * Pharmacy: Take your coupon to one of the 70,000 participating retail pharmacies (CVS, Walgreens, etc.).
- Direct: Use the portal to link directly to manufacturer platforms like LillyDirect or PfizerForAll for temperature-controlled home delivery.
- Valid Prescription Required: You still need a valid prescription from your doctor. If you don't have one, some integrated portals (like PfizerForAll) offer a telehealth consultation.
Medicare & Medicaid: The 2026 "Coverage Reset"
For the first time in history, Medicare is now covering weight loss medications for obesity through a special CMMI Pilot Program.
- The $50 Cap: If you are a Medicare beneficiary with obesity (even without diabetes), you are eligible for a flat $50 monthly copay for Wegovy or Zepbound.
- Medicaid Access: State Medicaid programs now have access to the $245 "Most-Favored-Nation" price, allowing them to expand coverage to millions of low-income Americans.
The Retatrutide Connection: What Happens Next?
While TrumpRx currently focuses on existing drugs, the administration has signaled that "Next-Gen" Triple Agonists like Retatrutide will be prioritized for expedited FDA review and immediate inclusion on the TrumpRx portal.
Industry analysts expect that once Retatrutide (the "Triple G" molecule) is approved in late 2026/2027, it will likely follow the $350 cash-pay pricing model established by Wegovy and Zepbound.
Important Warnings & Disclosures
- Conflicts of Interest: The portal has faced scrutiny from some members of the Senate regarding ties to the president's family and certain telehealth partners like BlinkRx.
- Insurance Limitations: TrumpRx is a cash-pay system. These purchases typically do not count toward your private insurance deductible.
- Medical Safety: Always consult a healthcare provider. High prescribing rates through some telehealth partners have led investigators to warn about "virtual pill mills".